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Abstract From its current vantage point, the future of US STEM education may appear bleak. Yet STEM education's strength and importance have never been greater, and evidence points to a bright future. This case can be made by drawing on the United State's identity as the world's most entrepreneurial nation. The optimistic outlook for STEM education is framed here through the lens of product-market fit—an economics concept describing how well-aligned products and market forces can generate self-sustaining demand. An analysis of these forces suggests that US STEM education has not only achieved this fit but surpassed it. The nation's strategic interests drive unmet demand for a well-prepared STEM workforce. Course-based research and inquiry-based teaching offer a superior educational model that can scale nationally. Life sciences, in particular, can combine broad student reach with low-cost DNA sequencing to create a multidisciplinary platform for education and research. As a grateful recipient of the Genetics Society of America's Elizabeth W. Jones Award, I reflect on how the Cold Spring Harbor Laboratory DNA Learning Center (DNALC) has operated at the intersection of these forces—developing infrastructure and approaches that are widely adopted and poised for expanded distribution. Meeting the nation's urgent need requires bold investment and broad engagement. By seizing this moment, we can make now the best time to be a STEM educator.